20th Century Boys 2: The Last Hope
- Cast: Toshiaki Karasawa, Etsushi Toyokawa, Takako Tokiwa, Airi Taira, Nana Katase
- Duration: 140 minutes
- Genre: Science Fiction, Adventure, Mystery
- Rating: 6.7/10
- Release Date: 2009-01-30
Set 15 years after "Twentieth Century Boys," Kanna (Airi Taira) reunites with several main characters from the first film in an attempt to stop Friend's increasing influence over the world and continued plans to eliminate humanity, as detailed in the New Book of Prophecy.
